Since Emmanuel Clase blew the save on Opening Day, it opened the door for Paul Sewald to come in an record a save in extra innings.
Since the role of closer was first established (roughly the late 1960s, early 1970s), only two pitchers have recorded a save on Opening Day for Cleveland who did not lead the team in saves that year (which is obviously likely the case for Sewald).
In 2014, John Axford recorded the save. He was the Opening Day closer, but Cody Allen was given the job later that year and would lead the team in saves.
In 1997, Paul Shuey recorded the Opening Day save. He was filling in as closer at the start of the year for Jose Mesa, who was inactive due to his active rape trial.