| Date | Player | Opp | Pitchers | Rslt | HR | RBI | BOP | Pos | Notes |
|---|---|---|---|---|---|---|---|---|---|
| 8-Jun-2023 | Jose Ramirez | BOS | Matt Dermody (2), Corey Kluber | W 10-3 | 3 | 5 | 3 | 3B | HR in first 3 AB, 0-2 after |
| 2-May-2018 | Edwin Encarnacion | TEX | Matt Moore (2), Jesse Chavez | W 12-4 | 3 | 6 | 5 | DH | |
| 9-Jun-2014 | Lonnie Chisenhall | at TEX | Nick Martinez, Scott Baker (2) | W 17-7 | 3 | 9 | 5 | 3B | Tied franchise RBI record |
| 17-Sep-2010 | Shin-Soo Choo | at KCR | Kyle Davies, Bryan Bullington, Greg Holland | W 11-4 | 3 | 7 | 3 | RF | |
| 20-Jul-2004 | Travis Hafner | at ANA | Jarrod Washburn (2), Francisco Rodriguez | W 14-5 | 3 | 6 | 6 | DH | |
| 16-Jul-2004 | Victor Martinez | at SEA | Travis Blackley, Ron Villone, Julio Mateo | W 18-6 | 3 | 7 | 4 | C | |
| 6-Jul-2001 | Jim Thome | STL | Matt Morris (2), Mike James | W 14-2 | 3 | 6 | 5 | 1B | |
| 19-Jun-2001 | Ellis Burks | MIN | Eric Milton (2), Bob Wells | L 9-10 | 3 | 3 | 2 | DH | |
| 25-Aug-1999 | Manny Ramirez | at OAK | Mike Oquist, Jason Isringhausen, Jimmy Haynes | W 12-4 | 3 | 4 | 4 | RF | |
| 15-Sep-1998 | Manny Ramirez | TOR | Dave Stieb (2), Paul Quantrill | W 7-5 | 3 | 5 | 4 | RF | |
| 25-Apr-1997 | Matt Williams | at MIL | Scott Karl, Ron Villone, Jose Mercedes | W 11-4 | 3 | 4 | 4 | 3B | |
| 19-Sep-1995 | Albert Belle | at CHW | Luis Andujar, Scott Radinsky, Rod Bolton | W 8-2 | 3 | 3 | 4 | LF | Also drew intentional BB |
| 22-Jul-1994 | Jim Thome | CHW | Jason Bere, Scott Sanderson (2) | W 9-8 | 3 | 3 | 3 | 3B | |
| 17-Jun-1993 | Carlos Baerga | at DET | Mike Moore (3) | L 5-9 | 3 | 5 | 3 | 2B | |
| 6-Sep-1992 | Albert Belle | SEA | Brian Fisher, Rich DeLucia | W 12-9 | 3 | 5 | 4 | LF | Also drew IBB and was pulled from game, missing out on 3 more PA |
| 19-Jul-1989 | Joe Carter | at MIN | Allan Anderson (2), German Gonzalez | W 10-1 | 3 | 6 | 4 | LF | Only player with a SB in the game |
| 24-Jun-1989 | Joe Carter | at TEX | Charlie Hough (3) | W 7-3 | 3 | 3 | 3 | CF | |
| 3-Jul-1987 | Brook Jacoby | CHW | Bill Long (2), Jim Winn | L 9-14 | 3 | 3 | 8 | 3B | |
| 28-May-1987 | Joe Carter | at BOS | John Leister, Tom Bolton, Wes Gardner | L 8-12 | 3 | 5 | 4 | 1B | |
| 21-May-1987 | Cory Snyder | MIN | Bert Blyleven (2), Mark Portugal | W 6-3 | 3 | 3 | 7 | RF | 2nd game including HR vs HOFer |
| 29-Aug-1986 | Joe Carter | at BOS | Tom Seaver, Sammy Stewart, Bob Stanley | W 7-3 | 3 | 4 | 3 | RF | 1st game including HR vs HOFer |
| 19-Jun-1973 | George Hendrick | DET | Woodie Fryman (3) | W 8-7 | 3 | 4 | 3 | CF | Hit walk-off HR |
| 24-May-1970 | Tony Horton | NYY | John Cumberland (2), Fritz Peterson | L 7-8 | 3 | 4 | 4 | 1B | Also drew intentional BB |
| 9-Jul-1961 | Willie Kirkland | CHW | Cal McLish (3) | L 8-9 | 3 | 4 | 5 | RF | Attempted sac bunt in 9th inning |
| 10-Jun-1959 | Rocky Colavito | at BAL | Jerry Walker, Arnie Portocarrero (2), Ernie Johnson | W 11-8 | 4 | 6 | 4 | RF | Only 4-HR game |
| 5-Jul-1954 | Bill Glynn | at DET | Ralph Branca, Ted Gray, Dick Weik | W 13-6 | 3 | 8 | 1 | 1B | Hit only 10 career HR (5 in 1954) |
| 29-Apr-1952 | Al Rosen | at PHA | Alex Kellner, Harry Byrd, Tex Hoyle | W 21-9 | 3 | 7 | 3 | 3B | |
| 20-Jun-1951 | Bobby Avila | at BOS | Bill Wight, Ellis Kinder, Paul Hinrichs | W 14-8 | 3 | 4 | 2 | 2B | |
| 2-Aug-1950 | Larry Doby | WSH | Connie Marrero (3) | W 11-0 | 3 | 5 | 3 | CF | |
| 13-Jul-1945 | Pat Seerey | at NYY | Atley Donald, Monk Dubiel, Steve Roser | W 16-4 | 3 | 8 | 3 | RF | |
| 25-May-1939 | Ken Keltner | at BOS | Emerson Dickman (3) | W 11-0 | 3 | 3 | 6 | 3B | |
| 5-Jul-1937 | Hal Trosky | at SLB | Oral Hildebrand (2), Sheriff Blake | W 14-4 | 3 | 7 | 4 | 1B | |
| 30-May-1934 | Hal Trosky | CHW | Les Tietje (2), Phil Gallivan | W 5-4 | 3 | 4 | 6 | 1B | Rookie year; Hit go-ahead HR in 8th inning |
| 17-Sep-1930 | Earl Averill | WSH | Bump Hadley (2), Firpo Marberry | W 13-7 | 3 | 8 | 3 | CF | Also hit HR in Game 2 of DH |